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May 2004

Gene-altered rice is hot issue

Capital biotech firm gets static from several sides

May 31
Sacramento Bee

A handful of anti-biotech activists descended on Ventria Bioscience last week with an "eviction notice" and a moving van, bluntly inviting the Sacramento company that grows pharmaceuticals in rice to leave the state.

Ventria's proposal to grow its novel product is scheduled for review again Tuesday morning by a rice industry panel in Yuba City.

But the street theater signaled that the company's plans to ramp up production are catalyzing concerns about manufacturing drugs in food crops.

"This has provided a really graphic wake-up call," said Renata Brillinger, campaign coordinator at Californians for GE-Free Agriculture in Occidental. "It's such a sci-fi thing."

Not just the activists are concerned. In Japan, the influential Rice Retailers' Association said it would seek a ban on California rice imports if genetically modified, or GM, rice is grown commercially in the United States.

"We think it is practically impossible to guarantee no GM contamination in non-GM (rice)," the industry group said in a statement handed out by the Japanese Consulate in San Francisco.

Californians also have taken notice. Many Sacramento Valley rice farmers are wary, even though Ventria promised to grow its rice only in counties where no commercial food rice is grown.

San Luis Obispo was one of 10 counties Ventria could target for its "pharma" crop, which has been engineered to produce two common human proteins, lactoferrin and lysozyme. The company envisions using them in anti-diarrheal treatments.

After reading newspaper reports about the possibility of the novel crop in San Luis Obispo, an unsettled county Board of Supervisors ordered a review of what it could mean.

Supervisor Peg Pinard was annoyed that the county had no say in a plan that affects its top industry, farming. "We should certainly have major involvement in what goes on here," Pinard said. "I want to ... only proceed with caution."

At the state level, Byron Sher, chairman of the Senate Environmental Quality Committee, is requesting an environmental review before the California Department of Food and Agriculture decides whether Ventria can ramp up production beyond its current test plots.

"I am ... concerned that action on this is being contemplated before the potential environmental impacts have been adequately considered," the Palo Alto Democrat said in a letter to the agriculture agency.

Sher has yet to get a response, but a CDFA spokesman said the agency would follow applicable environmental laws when it takes up the Ventria plan.

That could be soon, if Tuesday's meeting of the 12-member rice industry panel goes smoothly.

The panel, set up by state legislation to keep rice varieties separate, in March approved a strict set of procedures that would allow Ventria to become the nation's first commercial-scale producer of plant-made pharmaceuticals. The goal was to ensure the company's rice doesn't mix with food rice.

Next, the plan went to the CDFA, which was inundated with more than 1,400 letters - many of them form letters, and virtually all of them wary about growing drug compounds in open fields.

A few, however, echoed Ventria's hopes that "biopharming" offers cheaper drugs. "To halt or discourage the important research being conducted in the state of California would be a grave mistake," said the Society for Women's Health Research in Washington, D.C.

CDFA didn't sign off on the company's plan, saying the public needs more time to weigh in. It also told the rice panel to figure out how to track Ventria's federal permits, the subject of Tuesday's meeting.

When that's done, the plan goes back to the state for review, including a public comment period expected later this year.

Ventria officials, reportedly considering moving their growing program out of state, are keeping a tight lid on their plans. "We are still looking at our options," said company spokeswoman Brandy Rabe.

The organic activists who dropped in on Ventria last week say they will hound the company wherever it goes.

"We don't want you here ... or anywhere on the planet," said Ryan Zinn, trade director at Organic Consumers Association in San Francisco.