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News

March 2004

'Pharmaceutical' rice plan advances in state

A commission backs Ventria's proposal to plant the genetically altered grain to make medicinal proteins

March 30
Los Angeles Times

The state's rice industry on Monday narrowly backed a Sacramento company's plan to launch the first large-scale planting in California of a genetically engineered crop for use in medicines.

Ventria Bioscience needs approval from the state Department of Food and Agriculture before it can begin growing so-called pharmaceutical rice, which has been modified to produce two types of human proteins. The endorsement by the California Rice Commission was forwarded to the agency with the request that it quickly review the plan so Ventria could begin planting in mid-April, the start of the rice season.

Ventria's rice plants act as mini-biological factories to produce two proteins, lactoferrin and lysozyme. The proteins, which inhibit the growth of bacteria and viruses, would be extracted from the rice after harvest. . The rice isn't intended for human consumption.

Privately held Ventria sees a market potential of as much as $500 million for the compounds, which could be administered as pills or in oral-rehydration solutions, such as electrolyte drinks, said Chief Executive Scott Deeter.

Such products would require U.S. Food and Drug Administration approval.

California farmers already grow genetically engineered cotton for commercial use, and there are other modified crops grown elsewhere around the country.

But the rice commission's 6-5 vote, which came after three hours of debate, underscored the larger controversy surrounding the use of genetically modified organisms.

In particular, the planting of genetically altered crops intended for use in pharmaceuticals became a hot-button issuetwo years ago when corn modified to make a pig vaccine tainted soybeans in Nebraska.

The incident forced ProdiGene Inc., the College Station, Texas, company that produced the engineered corn, to destroy half a million bushels and compensate farmers $3 million.

Just last week, the North American Millers Assn. sent a letter to the U.S. Department of Agriculture urging more stringent regulatory oversight of such crops.

The letter warned that "the risk of adulteration from genetic material" modified for pharmaceutical or industrial uses entering the food chain was, in its view, "unacceptable."

On Monday, environmentalists and a number of rice farmers objected to Ventria's plan for fear the genetically engineered grain could contaminate California's existing rice crop and hurt exports.

Greg Massa, who farms 700 acres of rice in Colusa and Glenn counties, said that growing such a crop in California would be "bad news" for the state's rice industry. The decision, he said, endangers sales to Japan, the industry's biggest rice buyer, and other countries.

"We need to be able to say for marketing purposes that there is no genetically modified rice grown commercially in California," Massa said.

About 43% of California's $372-million rice crop was exported last year. All told, farmers produce 2 million tons of rice grown on more than 500,000 acres, mostly in Northern California.

The rice commission approved Ventria's plan after agreeing the company had adequate safeguards for keeping the grain out of the food supply.

Most significantly, the rice would be planted in Southern California, hundreds of miles from the counties — Colusa, Sutter, Butte, Glenn and Yuba — where nearly 90% of the state's rice is grown.

The firm also has stringent rules on how the pharmaceutical rice will be processed and on how equipment to farm and transport it can be used, said Tim Johnson, chief executive of the rice commission.

"We feel very confident that we will be able to keep this completely separate," Johnson said.

Rice typically is a self-pollinating plant — it doesn't use pollen from other rice plants to reproduce. When it does cross-germinate, the pollen lasts for just a few hours, only long enough to reach plants that are within 10 to 20 feet, according to biologists.

Although "you can never be 100% certain," said Peggy Lemaux, a plant biologist at UC Berkeley, Ventria appears to have developed a prudent plan for containing the genetically engineered rice.

Small plots of Ventria's modified rice are being grown at undisclosed sites in the state under an experimental exemption.


Waiter, there's a drug in my rice

March 30
Wired News

The California Rice Commission on Monday approved a biotech company's request to grow the state's first crop genetically modified to contain a drug.

The rice commission narrowly passed the proposal by a 6-5 vote. The commission advises the California Department of Food and Agriculture, which has the final decision on whether Ventria Bioscience of Sacramento can plant its pharmaceutical crop. If the agency approves, the company could be the first to commercialize such a product.

The rice is genetically modified to produce two human proteins that fight infection: lactoferrin and lysozyme. Some rice growers and environmental groups oppose the project, saying the rice could contaminate regular crops and damage the export market.

"Consumers in Japan will not accept (genetically engineered) contamination of any crop," said rice farmer Greg Massa in a statement. "The decision to approve Ventria's guidelines is bad news for farmers and California's rice industry."

But Ventria's proteins could be a big step forward in preventing infections in infants. Lactoferrin and lysozyme are present in breast milk, and protect babies from ear infections, diarrhea, respiratory tract infections, meningitis and other infections. But these protective proteins disappear when a baby stops breast feeding or doesn't receive breast milk at all. Researchers at Ventria were first to develop a human form of these proteins that could become therapies.

Ventria believes growing rice that produce proteins like lactoferrin and lysozyme in rice could be a cheaper way to develop drugs than building and maintaining expensive manufacturing plants.

But environmental groups and consumer advocates sued the U.S. Department of Agriculture in November 2003 for inadequate oversight of pharmaceutical crops. Companies like Dow Chemical and Monsanto are experimenting with corn, soybeans, tobacco, rice and sugar crops to find a cheaper way to mass-produce drugs.

Opponents say growing the crops in open fields endangers organic and conventional crops, as well as human health. And it's not just an issue environmentalists and consumer advocates are worried about, said Paul Achitoff, managing attorney of Earthjustice in Hawaii.

"Even food-processing corporations are very upset about this as well, because they know all you need is one shipment of corn flakes that has a contraceptive in it and there's a real problem, obviously," Achitoff said.

In 2002, federal officials ordered ProdiGene, of College Station, Texas, to burn 155 acres of corn and 500,000 bushels of soybeans because the crops had been contaminated by the company's pharmaceutical corn, which had been genetically engineered to produce an experimental diarrhea vaccine for pigs.

"Contamination is inevitable under this protocol, and the CRC did not act in the best interests of California rice farmers or consumers," said Renata Brillinger of Californians for GE-Free Agriculture.

"Instead of the normal 30-day public comment period that would exist with any other regulation, this fast tracking allows a 10-day review by CDFA," said Rebecca Spector of the Center for Food Safety. "The CDFA level is really the time where we depend on the public to be able to submit comments. We hope that the secretary of agriculture will review the proposal under the normal public review process."

"This is kind of a big mess," she said. "We requested that they wait to see how FDA and USDA are going to regulate this before approving this planting protocol. Ventria is taking advantage of this regulatory vacuum and in the meantime has gone through the regulatory bodies in California."

Ventria executives were not immediately available for comment.

Ventria's proposal restricts the production to counties that do not currently grow rice: San Luis Obispo, Kern, Santa Barbara, Ventura, Los Angeles, Orange, San Bernardino, Riverside, San Diego and Imperial.


Spermicidal cereal breakfast

March 17
ZNet

Just when the global diatribe over food and genetically modified crops (GM) is heating up in tone and breadth, the corporations that create them are staging a showcase for a fresh batch of transgenics.

These new GM crops, known as biopharmaceuticals, or biopharms for short, produce industrial and pharmaceutical chemicals within their tissues. The plants, including soy, rice, corn and tobacco, are genetically altered to produce substances such as growth hormones, curdling agents (coagulants), vaccines for humans (as well as farm animals), human antibodies, industrial enzymes, contraceptives and even pregnancy deterrents.

Scientists and corporations alike embrace biopharmaceuticals with glee: "Imagine being able to harvest enough globulin (a compound that fights arthritis) for the whole world in all of fifty acres?" writes Dr. William O. Robertson for the Seattle Post-Intelligencer. "Imagine being able to find the protein healthy people use to prevent arthritis or breast cancer and being able to produce it in large quantities in rice and tobacco."

ProdiGene, a leader in the field, calculates that by the end of this decade, 10% of the corn produced in the US will be biopharmaceutical. The volume of biopharmaceutical drugs and chemicals could reach the $200 billion figure, according to Dow AgroSciences' Guy Cardinau.

Warnings
But some scientists and ecologists are concerned. Will it be possible to contain and segregate such crops, fruit and seed, in order to avoid a biological Chernobyl?

Is there any guarantee that these products won't accidentally end up at the supermarket? And how can we keep their pollen from fertilizing other fields and reproducing out of control?

"One single mistake from a biotechnology company and we'll be having someone else's prescription medicine for breakfast in our cereal," warns Larry Bohlen, spokesman for Friends of the Earth, an international ecology organization.

"What will happen if the pollen of a transgenic plant containing some kind of drug fertilizes a nearby edible crop?" argues the Erosion, Technology and Concentration Action Group (ETC) in a report published in 2000.

The report continues to ask: "How will the soil microorganisms and insects which benefit agriculture be affected by crops genetically designed to produce industrial and pharmaceutical chemicals? What will happen if animals eat the biopharmaceutical crops? Will the biopharmaceutical proteins be altered during the various stages of growth, harvest and storage? Will they cause allergic reactions?

According to biologist Brian Tokar, professor at the Institute for Social Ecology, the most serious problems concern cross-pollination and unknown effects to insects, soil microorganisms and other native life-forms.

A Little Mishap In Nebraska
There have been mistakes with these crops already. In November 2002, at an agricultural cooperative in Aurora, Nebraska, 500,000 bushels of soy were contaminated with biopharmaceutical corn. One of the coop members harvested an experimental batch of corn for ProdiGene the year before and then proceeded to plant a crop of soy for human consumption in the same field.

During a routine inspection, federal officials from the Department of Agriculture found the corn stalks for ProdiGene growing among the soy plants. By the time they made the discovery, soy from that field was already being stored mixed with the soy of other coop members. Fortunately, the authorities were able to segregate the contaminated grain just before it reached the supermarket aisles.

The company was slapped with a $500,000 fine for negligence; yet, and in spite of such gross near disaster, the government still allows the corporation to continue with biopharmaceutical research as well as keeping the precise nature of the contaminating batch in Nebraska a trade secret. Mark Ritchie, president of the Institute for Agriculture and Trade Policy, describes the incident as the "Three Mile Island" of biotechnology, in reference to the emergency caused by a nuclear reactor in the 70s.

After the ProdiGene scandal, two industrial corporations which had so far supported transgenic research began to reconsider their positions. The Grocery Manufacturers Association, a group which represents supermarket distributing companies, expressed concern about the possibility that biopharmaceuticals could end up contaminating food supplies; such concern was also shared by the National Food Processors Association. The president, John Cady, requested strict and mandatory regulations in order to protect food products from being contaminated by biopharms.

Other people don't share such concerns. The Biotechnology Industry Organization, a group that represents biotech companies, and the American Farm Bureau Federation, an organization dedicated to Big Farming, are currently lobbying in Washington to obtain support from the federal government in order to weaken biopharmaceutical regulations.

Biological contamination
Transgenic products unfit for human consumption have already contaminated the food chain. At the end of the year 2000, environmental and consumer advocacy groups in the United States discovered that hundreds of american products in the supermarkets had been contaminated with traces of Starlink, a genetically enhanced GM corn that was declared unfit for human consumption by the Food and Drug Administration (FDA).

Although the Starlink strain was farmed in just 0.04% of the US corn production area, and was only meant for farm animal consumption, it ended up tainting 430 million bushels and to this day keeps showing up regularly in US exports.

"The Starlink discovery in Japan and South Korea, two of the most important US corn consumers, indicates that it could be found anywhere," remarks Meena Raman, from Malaysia, coordinator in Asia for Friends of the Earth Transgenics Program. "Until the US and Aventis (the biotechnology company that created Starlink) controls contamination, no other countries should allow corn imports."

A more severe case of genetic contamination is taking place in Mexico, where the presence of GM corn has been documented since 2001. It continues to show up in rural farming communities, both peasant and indigenous, sown by small farmers who are not aware of the transgenic threat; and it is proliferating rapidly, across wild and mixed varieties, in spite of the Mexican government's ban on transgenic crops, in effect since 1998. This contamination deeply concerns environmentalists, scientists and farmers, since Mexico is the cradle of corn and axis of its diversity, rendering the long term consequences on the environment and human health uncertain.

In Mexico, people are distressed by the possibility that biopharmaceutical corn could be introduced in the country. Silvia Ribeiro, of the ETC organization, expresses great annoyance about the California-based company Epicyte, which ostentatiously declared having developed a spermicidal corn to be used as a contraceptive.

Ribeiro stated in La Jornada: "The potential of spermicidal corn as a biological weapon is outrageous, since it easily interbreeds with other varieties, is capable of going undetected and could lodge itself at the very core of indigenous and farming cultures. We have witnessed the execution of repeated sterilization campaigns performed against indigenous communities. This method is certainly much more difficult to trace."

We cover the world
Where are biopharms cultivated? All over the world. At the molecularfarming.com website, investors solicit the collaboration of farmers willing to lease their land for biopharmaceutical experiments anywhere in the world. They have signed agreements in Brazil, Ireland, Australia, Greece, Zimbabwe, Panama and many other countries.

Activist Beth Burrows first denounced the claims at the Molecular Farming's website. Burrows is president of the Edmonds Institute, a nonprofit dedicated to bioethics and biosecurity issues.

Award-winning journalist Devinder Sharma, an expert in agricultural and nutritional matters who lives in India, comments on molecularfarming.com: "This is part of a global scheme to transfer dirty industries onto the Third World."

"First came the exporting of toxic and industrial recycled waste to developing countries in Africa and Southeast Asia. Now comes the biopharms. In the US there's a huge problem regarding these crops. What are they gonna do? Transfer dirty technology."

Don't worry, be happy
In spite of all this, biopharming advocates assure us that they're perfectly safe. Doctor Allan S. Felsot, an environmental toxicologist at Washington State University considers the use of plants to produce pharmaceuticals and other chemicals "not even a new concept, if we take into account that we've used medicinal plants for centuries."

Felsot insists there's nothing unusual about our breeding human proteins in the tissues of transgenic plants. "The proteins (in question) are the same found in our bodies. Most of them are used as medicine through cellular fermentation. They are very well defined and have been subject to exhaustive research and clinical trials on humans."

Doctor Robertson adds: "The possibilities boggle the mind, the opportunities are impossible to grasp in their totality and the risks appear minimal when they're compared with the risks we have encountered in medicine throughout the years."

What's ahead?
"What will have to happen before the Department of Agriculture takes seriously the fact that millions of people almost ended up consuming experimental drugs and chemicals?" asks Brandon Keim, of the Council for Responsible Genetics in reference to the ProdiGene scandal. "A few sensational deaths? Maybe an increase in debilitating disorders which will only be noticeable some decades later, when it's already too late?"

Biopharmaceuticals are in an experimental stage but the corporations producing them anxiously await the day when federal authorities give them the go-ahead to enter the market.

Carmelo Ruiz is a journalist and a research associate of the Institute for Social Ecology. He has previously published in Grist, E Magazine, the New York Daily News, Corporate Watch, IPS and other media.


Feed corn, meet 'pharma corn'

French firm eyes Phillips County test plot for crop altered to grow pharmaceuticals

March 13
Rocky Mountain News

HOLYOKE -- Sally Brinkema placed her slight, suntanned hand on the gear shift and pulled the tractor-trailer into reverse.

As gold-yellow corn poured from a silver Quonset hut into her truckbed, Brinkema gazed at the winter stalks of her family's cornfields as she talked about the risks of farming.

There's the 50-cents-a-bushel less she's earning on this feed corn because of the mad cow scare. The monthly $21,000 electricity bills to pump ground water for irrigation. The three years that rain hasn't come, killing her winter wheat. And the two families down the road who went bust and sold their land to Sally Brinkema and her husband, Harry.

Slim margins and flat prices force farmers such as Brinkema to question the risk of each decision about the land. And risk lies at the heart of a new type of farming that may come to Phillips County, bringing higher-paying jobs and more expensive crops.

French pharmaceutical company Meristem Therapeutics received a permit last year to test a plot of genetically engineered corn at a secret site in Phillips County. The company wants to stake a claim in the U.S. pharmaceutical market, and its corn would solely produce ingredients for medicines.

Proponents argue that plant pharmaceuticals and processing plants - a growing billion-dollar industry - will revitalize depressed rural areas, ushering in a Silicon Valley of high-tech jobs to Holyoke and surrounding Phillips County. That, in turn, could lure young people back to the farm.

Farmers in this close-knit, eastern Colorado town of 2,800 are torn.

They understand they must embrace new technologies and take chances to prosper. But the project's secrecy bothers them, and they can ill afford an accident that might reach the news and stigmatize Colorado crops, which make up 40 percent of the county's economy.

"Farmers want to make sure they are protecting themselves, and ultimately, making some money," said Michelle Finley, executive director of Phillips County Economic Development Corp.

Environmental groups emphasize the risk of contaminating the food supply and the ecosystem.

But plant-made medicines are also 10 to 20 times cheaper to produce than current medicines, leading to cheaper drugs and drugs for hard-to-treat diseases.

"Wouldn't it be fabulous if you could raise medicine?" said Sally Brinkema, adding in her next breath, "I really don't see how it would fit into our current operations."

Corn for cystic fibrosis
After a morning of loading grain and ferrying it to the hog feedlot, the Brinkemas sit down to a lunch of ham sandwiches and homemade caramel cake. They live in a brick ranch house down a dirt road in the sand hills outside of Holyoke, amid 1,600 acres of farmland.

Harry Brinkema, who grew up farming, muses on the irony of a French company trying to grow genetically modified corn in the U.S.

France won't buy U.S.-grown GMO corn, a ploy most farmers believe is sheer protectionism.

Just a week ago the Brinkemas got a letter from their seed vendor asking them to promise to sell their genetically modified feed corn only to certain markets.

"We don't buy French wine anymore," Harry Brinkema said. "You'll find that most farmers are acutely aware of the business aspects of what they buy."

In fact, about 40 percent of U.S. corn seed is genetically modified, altered to resist insects and herbicides. And Meristem's corn follows that American tradition. It's made the same way that chemical maker Monsanto manufactures Roundup Ready corn, for instance. Except it has been jiggered to produce abnormal amounts of lipase.

The enzyme lipase is produced in the bodies of healthy adults. But it's missing in the digestive systems of people with cystic fibrosis, a genetic disorder that affects about 30,000 Americans.

Meristem has already produced one kilo of pharmaceutical-grade lipase from fields in France. The company is four months from completing phase II clinical trials to test this plant-grown lipase to create cystic fibrosis medicine. Currently, patients consume lipase derived from pancreases of pigs.

Meristem has said it can produce lipase 14 times more cheaply in corn.

"The cost savings could be significant," said Dr. Frank Accurso, a cystic fibrosis expert at Children's Hospital. "It's currently in the thousands of dollars per year per individual for cystic fibrosis."

Other companies are quietly following this trend: In 2002, the U.S. Department of Agriculture allowed more than 34 field trials of "pharm crops" across the country. Industry experts project the market for plant-produced pharmaceutical and industrial proteins could reach $200 billion by year 2010.

Most of this activity has taken place away from informed public discussion. Farmers fear that city folk, ignorant of farming, see only frightening images of "frankencorn."

"The world has such a scary perception of GMO corn," said Sally Brinkema. "But yellow peppers are a modification of green peppers. So are red. For some reason, the world panics at the thought of GMO corn.

"I'm worried that this 'pharma corn' will cause more fear."

Wooing the French
Meristem hasn't broken ground in Phillips County, but could any time during the planting season, which ends at the beginning of June. The company has also expressed an interest in greenhouses in Rifle and lab space at the former Fitzsimons Army Medical Center.

The company won the planting permit from the Colorado Department of Agriculture last year after three Colorado scientists approved its application.

"We had a long discussion with them. They answered questions and told us their strategies," said Pat Byrne, Colorado State University associate professor of soil and crop sciences. "They were very honest with us."

In September, a delegation of Colorado politicians visited Meristem's facility in Clermont-Ferrand, France. The delegation included Sen. Mark Hillman. R-Burlington; Rep. Ray Rose, R-Montrose; Rep. Diane Hoppe, R-Sterling; Jim Rubingh, director of markets of the state Department of Agriculture; and John Stencel, executive director of the Rocky Mountain Farmers Union.

They brought a letter from Gov. Bill Owens in which he expressed his "enthusiasm" for Meristem locating a pharmaceutical processing facility in Colorado.

They also toured a small test plot.

"It was the same color as normal corn," Stencel said. "It doesn't glow. It looked like a normal corn crop. No fence. No guards. A sign in French that said it was a research plot producing lipase."

Following the September visit, Meristem executives returned to Colorado in December. They toured a Rifle greenhouse as well as Fitzsimons. They met with Owens, state legislators, venture capitalists, University of Colorado President Betsy Hoffman and city officials from Rifle, Glenwood Springs and Battlement Mesa, said John Cevette, executive director of the Colorado Corn Growers Association.

"The climate of the discussions had been exceptionally positive with the people we met in Colorado," Meristem Chief Executive Jean-Paul Rohmer said in an e-mail.

Cevette said the company was very interested in Colorado.

"They felt very comfortable here," he said. "When they left in December, they had pretty much made up their minds that they would move to the U.S. and that Colorado would be their location."

A crop of questions
In the winter, Holyoke farmers gather daily at Schmidt's, a sandwich and pizza shop on Main Street.

With caps pulled down and vests pulled tight, a half-dozen men encircle a red table and quietly discuss the town's news. Few secrets escape this group, and controversy is avoided.

"Issues like this (pharmaceutical corn), they can quickly become divisive and painful," said Tom Balding, a furniture maker. "I don't put bumper stickers on my bumpers. I don't want anybody to know how I think."

If Meristem ever comes to Holyoke, these farmers have some questions. First, where is the site?

"In a small town, once you have secrecy, people don't trust you. The location is all secret," said farmer Kathy Schneller, 62.

Up until now, the company hasn't revealed the plot's location out of fear of vandalism.

Second, how much will the company pay farmers?

"The money will have to be pretty substantial," said Schneller.

So far, no monetary terms have been made public. Meristem says farmers will be paid per acre farmed.

Third, can the community live with the controversy?

"You have fanatics," said farmer Harry Brinkema. "People who start fires in ski cabins."

Fourth, why here?
"Why don't they want it in France?" Schneller asked. "They have a lot of trade barriers against us with GMO corn. That kinda gets me worked up."

Meristem says that the French public is "very supportive" of the development of new medicines, but "the information has been very biased, raising unjustified and irrational fear about any new technology."

The company wants to relocate some, or possibly all, of its operations to the U.S. because most of its potential partners are in the U.S. and because the scientific and political community here is more supportive of its work.

Further, the company wants to enter the U.S. because FDA approval is the gold standard, and finally, U.S. investors appear to be interested in Meristem's work.

Colorado would appear ideal because the cornfields are not as crowded as in the Midwest, allowing for greater separation between Meristem's corn and regular corn.

GMO in the wind
For Holyoke residents, the biggest concern is the wind.

The wind reaches 50 miles an hour here. Tumbleweeds skitter across the road, branches shake and car doors yank out of hands.

Farmers fear the wind will carry Meristem's corn pollen to neighboring fields, breeding genetic mutants.

Meristem calls for a 1.5-mile swath around its field. Tom Holtzer, who heads the department of Bioagricultural Sciences and Pest Management at CSU, says that should be enough.

Two studies done last year under Colorado's hot and dry conditions showed the farthest distance a corn plant could be pollinated by airborne pollen was one-tenth of a mile, Holtzer said.

Furthermore, Meristem's plants will be male sterile and detasseled every day. The fields will use dedicated equipment, and lie fallow for two years after harvest.

Still, some say these precautions don't go far enough.

Wildlife could graze in the corn. Insects might take microscopic amounts on their wings. The genes could enter the soil or groundwater. Farm workers could be exposed to unhealthy amounts of biopharmaceuticals.

A study published last month by the Union of Concerned Scientists said some unmodified corn, soy and canola seeds in the United States have been cross-pollinated by genetically engineered crops.

In the study, plant pathologist Jane Rissler said scientists should assume that engineered sequences originating in any crop could potentially contaminate the seed supply.

"Among the potential contaminants are genes from crops engineered to produce drugs, plastics and vaccines," Rissler wrote.

The Rocky Mountain Farmers Union urges caution.

"We are moving really quickly on an issue we don't know much about. We feel we need to go slow," said Stencil, the group's executive directorl.

"It's very dangerous," said Peter Crowell, vice president of the Uncompahgre Valley Association and board member of the Western Colorado Congress, a grass-roots citizens organization. "If you are going to raise these crops, you should do it in non-food, non-feed crops. Or do it indoors. The third option is to not do it at all."

Remember the hog farms
Holyoke seems a fairly prosperous rural town. Along its neatly manicured streets with tidy, green lawns it boasts a school, library, courthouse, hospital, drugstore, hardware store, grocery store and movie theater.

Still, it will need to grow.

"We need jobs," said Jim Keinholz, an innkeeper. "Jobs bring people. We need people to create taxes to pay for roads. You can't stay stable with the cost of government services going up."

Most farmers here see plant- made pharmaceuticals as a risk, but they know some risk is necessary.

"Everything in life, to me, is a risk," said economic developer Finley. "Opening a business is a risk. Progress is often a risk."

Meristem's processing facility would bring up to 50 white-collar technology jobs, each paying up to $50,000 - a generous salary in a town where houses cost $88,000, on average.

Nearly 15 years ago, Holyoke was equally divided over another issue: hog farms. Proponents said the indoor pens would bring jobs and bigger markets for Holyoke corn. Detractors complained about the smell, water pollution and workers from outside the county.

The hog farms were built, and for a time, not a single house was for sale in Holyoke. The local trucking firm added trucks to transport swine, and local stores enjoyed more customers.

The townspeople are proud to point out that their hog farms followed environmental regulations carefully, and as a result have suffered no problems.

These days, the swine operations buy the lion's share of the town's corn, and Finley doesn't know if anybody still objects to them.

"At this point," she said, "it would be a travesty to remove them."